Pot Strains That Make You Laugh: The Best Strains for Giggles

 

Sometimes, all you need in life is a good laugh and maybe a little help from the perfect weed strain. 

Whether kicking back with friends, watching your favorite stoner comedy, or just looking to lift your spirits, certain pot strains have a magical way of turning giggles into full-blown laugh attacks. We’re talking about the most giggly strains out there, affectionately known as “giggle weeds.”

If you’ve ever wondered what strains of weed make you laugh until your sides hurt, you’re in for a treat. These strains tickets to lighthearted vibes, great times, and a much-needed escape from the everyday grind.

Stick around as we break down the pot strains that make you laugh and turn even the most serious situations into giggle-worthy moments. Your sense of humor is about to get a serious upgrade!

Let’s discuss why some weed strains can give you the giggles. 

Key Takeaways

• Cannabis can enhance laughter through THC’s interaction with dopamine and serotonin, elevating mood and amplifying humor.
• Terpenes such as limonene, myrcene, and caryophyllene play a significant role in boosting euphoria and reducing stress.
• Sativa-dominant strains are often ideal for giggles due to their uplifting and energetic effects, while hybrids offer a balanced experience.
• Factors like potency, cannabinoid profile, and terpenes are key when selecting a strain for laughter.
• Creating the right setting—such as a relaxed gathering or a comedy night—enhances the joy and humor cannabis can bring.
• Responsible consumption, including starting with low doses and staying hydrated, ensures a safe and enjoyable experience.

The Science Behind Cannabis and Laughter

Cannabis interacts directly with your brain and body to produce effects tied to laughter and joy. The plant’s cannabinoids, primarily THC, engage with the endocannabinoid system, which can alter mood and perception in ways that make you a bit more sociable and open to humor. 

This connection helps explain why cannabis is often associated with feelings of euphoria and lightheartedness. That said, how exactly does THC interact with the brain to give you a serious case of the giggles? 

The Role of Dopamine

The brain’s limbic system, responsible for processing emotions and rewards, plays a significant role in why cannabis can make you laugh. 

When THC binds to CB1 receptors in this region, it triggers a chain reaction that stimulates the release of dopamine, a neurotransmitter heavily associated with pleasure, motivation, and happiness. 

Elevated dopamine levels can create heightened enjoyment and amusement, making even mundane situations or small jokes seem incredibly funny.

Also, THC's influence on this system can lower your emotional inhibitions, encouraging you to relax and immerse yourself more fully in the moment. 

This combination of reduced self-consciousness and amplified emotional responses can make humor feel more vivid and laughter more effortless. By altering how your brain interprets and reacts to stimuli, cannabis transforms ordinary experiences into joy and hilarity.

The Role of Serotonin

THC doesn’t just affect dopamine levels. It may also influence serotonin, another key neurotransmitter involved in mood regulation. Serotonin plays a central role in feelings of well-being, relaxation, and emotional stability. 

Research suggests that THC can increase serotonin levels in certain parts of the brain, particularly in low to moderate doses. This boost in serotonin may help elevate mood, reduce anxiety, and create a lighter, more carefree mental state.

When serotonin levels are heightened, it becomes easier to find joy in everyday moments, including humor. This mood enhancement could make you more receptive to funny situations, leading to a greater likelihood of giggling or outright belly laughs. 

Also, elevated serotonin often correlates with reduced stress, which helps strip away emotional barriers and self-consciousness, making it easier to let loose and enjoy a good laugh.

This serotonin-dopamine combo of THC boosting both "feel-good" chemicals might explain why certain strains that make you laugh seem to transform mundane moments into comedic gold. 

Whether you're chuckling at a clever pun or cracking up over a ridiculous meme, serotonin's mood-boosting effects likely play a big role in those fits of cannabis-induced giggles.

The Influence of Terpenes

The euphoric effects of cannabis are a result of more than just THC. Terpenes, the aromatic compounds responsible for cannabis's distinct scents and flavors, also play a significant role in shaping your experience. 

These terpenes can interact with THC and other cannabinoids in a phenomenon known as the entourage effect, enhancing or modifying the high. Certain terpenes, such as limonene and myrcene, may directly contribute to those uncontrollable fits of giggles.

Limonene

Limonene, commonly found in citrus fruits and many cannabis strains, is renowned for its uplifting and mood-enhancing effects. This terpene may influence the brain's serotonin system, potentially increasing serotonin levels or sensitivity. 

Since serotonin is linked to happiness and relaxation, limonene-rich strains might help create a cheerful, lighthearted state where even mundane situations feel amusing.

Limonene's ability to reduce stress and anxiety further sets the stage for laughter. By calming negative emotions, this terpene can make you more receptive to humor and spontaneous joy, often leading to the giggles when combined with THC's effects.

Myrcene

Myrcene, one of the most common terpenes in cannabis, is known for its sedative and calming properties. 

While it’s typically associated with relaxation and easing tension, its role in enhancing euphoria shouldn't be underestimated. By helping the body and mind unwind, myrcene creates an ideal environment for dopamine release triggered by THC, amplifying feelings of happiness and pleasure.

This relaxation can make you feel more carefree and less inhibited, conditions that often lead to laughter. Myrcene-rich strains may also reduce social anxiety, allowing for more open interactions and shared jokes, which can snowball into bouts of infectious giggling.

Now that we know why cannabis makes you laugh, let’s take a look at what you need to consider when choosing the best strains to make you giggle.

How to Choose the Best Strain for the Giggles

If you're on the hunt for a cannabis strain to fill your day with laughter, here are the key factors to consider. Picking the right strain isn’t just about its THC content. It’s about finding the perfect balance of cannabinoids, terpenes, potency, and flavor to bring out those uncontrollable giggles.

Here’s how to choose the best strains to make you laugh: 

Cannabinoid Profile

Cannabinoids like THC and CBD play a pivotal role in how cannabis affects your mood. For giggles, you’ll want a strain with moderate to high THC levels, as THC binds to receptors in your brain’s reward system, releasing dopamine and creating euphoria. 

However, if you’re prone to anxiety, look for strains with a bit of CBD to help balance out the effects and keep you relaxed. Some blends also include minor cannabinoids like CBG or THCp, which can subtly enhance the experience and make laughter come more naturally.

Potency

Potency matters, especially if you aim to laugh until your stomach hurts. High-potency strains, those with THC levels above 20%, are often ideal for experienced users who can handle a strong cerebral buzz.

Beginners might prefer mid-potency strains (15 to 20% THC) to avoid overwhelming effects. Remember, you’re looking for euphoria and fun, not a high so strong that it leaves you spaced out or lethargic.

Terpenes

Terpenes, the aromatic compounds in cannabis, are a game-changer when it comes to your high. 

For giggles, seek strains with:

• Limonene: Uplifting and mood-boosting, limonene can enhance your sense of humor and positivity.
• Myrcene: Known for its relaxing effects, myrcene helps reduce tension, making it easier to let loose and laugh.
• Pinene: A touch of pinene sharpens focus, so you can fully engage with the jokes and conversations.
• Caryophyllene: Adds a layer of calm and grounding, ensuring you don’t spiral into an overly intense high.

Strains rich in these terpenes tend to spark creativity, amplify humor, and create an atmosphere where laughter flows freely.

Strain Type: Sativa, Indica, or Hybrid?

For laughter, sativa or sativa-dominant hybrids are often the way to go. Sativas deliver an energetic, cerebral high that boosts creativity and social engagement, perfect for funny conversations or watching a comedy special. 

Hybrids can be a great middle ground, offering both uplifting effects and a touch of relaxation to keep you at ease. Indica-dominant strains, while calming, may lean more toward sedation and aren’t as ideal for giggly moments.

Flavor and Aroma

While flavor might seem secondary, it contributes to the overall experience. Strains with sweet, fruity, or citrusy profiles, like Strawberry Amnesia or Berry Pie, tend to feel more playful and fun. 

On the other hand, earthy or diesel-flavored strains like Chemdawg can add a bold, invigorating touch to your high. A flavor you enjoy enhances the entire experience, making those giggle-inducing moments all the more satisfying.

Now that you know how to choose the best strains to make you laugh, let’s look at the top five giggle-inducing strains. 

Best Pot Strains That Make You Laugh: Top Five

Right now, we want to look at the top five THC strains that make you laugh, including fan favorites such as Chemdawg, Green Crack, and Strawberry Amnesia. 

Chemdawg

Chemdawg is the stuff of legends. This 55% indica, 45% sativa hybrid has mysterious origins, rumored to involve a Grateful Dead concert and some “lucky” seeds. 

With 19% THC, it delivers a high that’s the best of both worlds: a heady, creative buzz balanced by a deeply relaxing body high. Oh, and fun fact: Chemdawg is the proud parent of the iconic Sour Diesel.

This strain doesn’t hold back on aroma or flavor, with its diesel, earthy, and piney notes practically shouting from the jar. Its terpene lineup, including caryophyllene, myrcene, and limonene, amps up the effects, making it a hit for stress relief and creativity.

Chemdawg is perfect for sparking those laugh-till-you-cry moments. The cerebral high sharpens your wit and humor, while the mellow body vibes keep you comfy as you giggle at even the silliest jokes. It's great for movie night or deep conversations that spiral into hilarity!

Here’s a fantastic Chemdawg product to get you started. 

Euphoria Blend 4ml Live Resin Disposable Vape - Chemdawg 

Chemdawg is a hybrid powerhouse that blends creative energy with full-body relaxation. Infused with HHC, Delta 8, H4CBD, CBG, and THCp, this live resin disposable vape delivers a flavorful punch of lemon, pine, and diesel that’s both refreshing and bold. 

The high starts with an invigorating cerebral rush, sparking creativity and a sense of euphoria that can lead to contagious laughter. 

As the effects deepen, a soothing body high takes over, easing tension and stress without leaving you couch-locked. Chemdawg is ideal for enjoying group conversations, sharing jokes, or even a relaxed evening at home. Its ability to spark humor and keep the mood light makes it a fantastic choice for anyone looking to laugh, unwind, and have a good time.

Strawberry Amnesia

Strawberry Amnesia is a 70% sativa-dominant hybrid that’s like sunshine in cannabis form. A lovechild of Strawberry Cough and Amnesia, it packs a flavorful punch of fresh strawberry sweetness with earthy undertones and THC levels between 20% and 22%.

This strain stands out because of its terpenes, including terpinolene, myrcene, and pinene, which team up to deliver a creative, euphoric buzz. 

It’s energizing but not overwhelming, making it great for daytime adventures. The high kicks off with a burst of mental clarity and focus, making everything feel just a little funnier.

If you’re looking for a giggle-packed smoke session, Strawberry Amnesia delivers. Whether cracking jokes with friends or just laughing at your silly thoughts, this strain’s uplifting vibes make it easy to find humor in anything.

Here’s a Strawberry Amnesia vape that is so potent it might just make you forget what you started laughing about in the first place. 

Euphoria Blend 2ml Disposable Vape - Strawberry Amnesia

Strawberry Amnesia is a sativa blend that’s all about good vibes and energy. Combining Delta 8, HHC, CBN, CBD, and THCp, this vape captures the essence of its parent strains, Strawberry Cough and Amnesia. 

The flavor is a delightful mix of sugary-sweet strawberries and earthy undertones, evoking the taste of freshly picked fruit. The high is where this vape truly shines, starting with a euphoric cerebral boost that sharpens your focus and energizes your mood. 

Its cheerful and uplifting effects naturally lead to laughter, making it the perfect choice for social settings or light-hearted solo moments. Whether you’re swapping stories or enjoying a funny movie, Strawberry Amnesia’s mood-enhancing properties ensure every moment feels just a little more delightful.

Green Crack

Don’t let the name throw you off because Green Crack is 100% cannabis and 100% awesome. This 65% sativa-dominant hybrid brings a THC range of 15-25%, offering an energizing, feel-good high that’s hard to beat. Born from Skunk #1, it’s famous for its citrusy, mango-sweet flavors that make every hit a treat.

The terpenes, including myrcene, pinene, and caryophyllene fuel Green Crack’s signature effects: focus, creativity, and a big ol’ mood boost. It’s the kind of high that gets you laughing at the smallest things, like your cat being a little too dramatic while chasing a string.

Green Crack is perfect for daytime shenanigans or brainstorming sessions that turn into comedy gold. It’s like a ticket to Giggletown, with just the right kick of mental energy to keep you going.

Here’s a great example of a Green Crack product that will surely crack you up!

Euphoria Blend 2ml Live Resin Disposable Vape - Green Crack

Green Crack is a sativa lover’s dream, offering a burst of energy and uplifting effects that keep you buzzing. This live resin disposable vape features a blend of Delta 8, HHC, CBN, CBG, and THCp, creating a potent formula designed to amplify your mood and fuel your day. 

Its bright, tangy flavor combines notes of mango, citrus, and tropical fruits, leaving a refreshing taste with every puff. Known for its cerebral stimulation, Green Crack helps you focus and sparks creativity while bringing a sense of light-hearted joy that can lead to fits of giggles. 

Whether tackling a busy day or hanging out with friends, this strain’s ability to enhance humor and positivity makes it a top choice for those looking to laugh their way through the day.

Jealousy

Jealousy is a 50/50 hybrid that’s as balanced as it gets. With 28-30% THC, it’s got some serious kick, but don’t worry because it’s all good vibes. A cross of Gelato 41 and Sherbet, this strain combines a creamy, fruity-candy flavor with a zing of sour citrus that’s just plain delicious.

Its terpene trio, including caryophyllene, limonene, and linalool, delivers a high that’s both uplifting and chill. The head buzz sparks creativity and motivation, while the body high keeps you relaxed enough to enjoy the ride. This combo is prime for turning even the most mundane moments into laugh-out-loud memories.

Jealousy shines in social settings, so bring it out when you’re looking to swap stories, tell jokes, or just vibe out with friends. It’s the kind of strain that makes life feel lighter and way more amusing.

Let’s take a look at a great Jealousy vape to get you laughing.

Euphoria Blend - Terp Sauce 1ml Disposable Spinner Vape - Jealousy 

Jealousy strikes the perfect balance between uplifting and relaxing effects, making it a must-have hybrid for mood elevation and good times.

Infused with a potent combination of HHC, Delta 8, H4CBD, CBD, CBG, and THCp, this vape blends a fruity sweetness with notes of citrus and earthy undertones for a complex and satisfying flavor. 

The high begins with a cerebral lift, giving you an energetic sense of euphoria that can quickly lead to contagious laughter. As the effects settle, a gentle wave of relaxation spreads through your body, keeping you calm and focused without weighing you down. 

Whether catching up with friends or diving into a creative project, Jealousy’s giggle-inducing high and smooth flavor profile makes it an unbeatable companion.

Berry Pie

Berry Pie is like dessert in a joint. This 60% indica-dominant hybrid, a mix of Girl Scout Cookies and Blueberry, brings a sweet, fruity flavor that tastes just like, you guessed it,berry pie, complete with a nutty vanilla finish. With THC levels hitting 21-25%, it’s as potent as it is tasty.

Packed with myrcene, pinene, and limonene, this strain delivers a calm, happy high with a touch of mental clarity. The body buzz melts away stress, while the head high puts you in a playful, giggly mood.

Whether you’re binge-watching your favorite sitcom or swapping funny stories, Berry Pie sets the stage for good vibes and belly laughs. It’s perfect for those moments when you just want to kick back, relax, and let the giggles take over.

Here’s a great Berry Pie vape that will get those giggles flowing. 

Euphoria Blend - Terp Sauce 1ml Disposable Spinner Vape - Berry Pie 

This sativa-forward vape is a joyful escape wrapped in flavor. Packed with cannabinoids like HHC, Delta 8, H4CBD, CBD, CBG, and THCp, Berry Pie delivers a well-rounded high that uplifts your spirits and clears away stress. 

The flavor profile is a luscious blend of creamy berries complemented by a subtle kick of citrus and peppery undertones. 

The high terpene content enhances the euphoria, making it perfect for those moments when you want to lighten the mood and spark uncontrollable giggles. 

Whether you’re cracking jokes with friends or simply enjoying a comedy special, Berry Pie has your back. It delivers a sweet sense of relaxation and creative energy that ensures laughter is always close by.

With the best strains to make you laugh covered, let’s review some tips on making the most out of your giggly experience.

Making the Most of Your Giggly Experience

Creating the perfect environment and using cannabis responsibly can really enhance your giggly moments. The right setting and thoughtful consumption help you enjoy laughter-filled times.

Let’s talk about the ideal setting for the giggles. 

Ideal Settings for Laughter

Here are a few ideas in terms of the best settings to be in either after or while consuming these giggle-inducing strains. 

• Relaxed Gatherings: A small group of friends or family encourages easy conversation and shared laughter.
• Outdoor Spaces: Parks, backyards, or other open-air places offer a refreshing backdrop for lighthearted fun; the fresh air can make everything feel more vibrant.
• Comedy Nights: Watching stand-up shows, sitcoms, or funny movies pairs well with uplifting strains; laughter is always a great companion.
• Creative Activities: Painting, writing, or gaming can spark joy and bring out the humor in unexpected ways.
• Music Sessions: Playlists with upbeat tunes add energy and enhance positive vibes, making everyone feel light and joyful.

Dosage Tips for the Best Experience

Getting the giggles is likely with these strains, but remember that there is such a thing as too much of a good thing. Therefore, keeping things in moderation is key. 

Here are some dosage tips for the best THC laugh: 

• Start Small: Try a single puff or a small dose, particularly if you’re new to cannabis or the specific strain.
• Stay Hydrated: Keep water nearby to avoid dry mouth and stay comfortable throughout.
• Monitor Effects: Give it 15 to 30 minutes before having more; effects might take a while to peak.
• Know Your Limits: Avoid going overboard to prevent overwhelming sensations or feeling stuck on the couch.

Final Thoughts on the Best Pot Strains to Make You Laugh

Choosing the right cannabis strain can transform an ordinary day into a laugh-filled adventure. The unique interaction between cannabinoids, terpenes, and neurotransmitters like dopamine and serotonin creates the perfect recipe for uncontrollable giggles. 

Whether relaxing with friends, enjoying a comedy special, or looking to elevate your mood, the strains highlighted in this article offer an ideal balance of euphoria, creativity, and humor.

Now armed with knowledge about the science behind cannabis-induced laughter and the top giggle-inducing strains, you’re ready to take your cannabis adventures to the next level. Let laughter lead the way as you explore these strains and discover the lighter side of life with Mellow Fellow.

Frequently Asked Questions

Why Do Some Strains Make You Laugh More Than Others?

Certain strains have higher levels of THC and specific terpenes, such as limonene and myrcene, that enhance dopamine and serotonin activity. These compounds influence your mood, lower inhibitions, and make you more receptive to humor, amplifying laughter.

Are Giggle-Inducing Strains Safe for Beginners?

Giggle-inducing strains are generally safe for beginners when consumed in moderation. New users should start with lower-potency strains or those with balanced THC-CBD ratios to avoid overwhelming effects and enjoy a lighthearted experience.

What Are the Best Times to Use Giggle-Inducing Strains?

The best times to use these strains include social gatherings, relaxing evenings, or creative activities. They’re perfect for situations where a cheerful, carefree vibe is desired, making interactions and entertainment more enjoyable.

How Can Terpenes Affect the Humor Response?

Terpenes like limonene and pinene work synergistically with THC to boost mood and reduce stress. By enhancing neurotransmitter activity and relaxation, they create the ideal mental state for humor and laughter to flourish.

Can Giggle-Inducing Strains Help Relieve Stress?

Yes, many strains known for inducing laughter also have calming and stress-relieving properties. The relaxation provided by terpenes like myrcene and caryophyllene, combined with THC’s euphoric effects, can help ease tension and promote joy.

How Can I Maximize the Laughter Effect of Cannabis?

To maximize laughter, pair your cannabis experience with activities that naturally spark joy, such as watching comedies, listening to upbeat music, or spending time with close friends. Choosing the right environment and starting with an appropriate dose are also key.

Sources

• The effects of Δ9-tetrahydrocannabinol on the dopamine system - PMC
• Serotonin Syndrome versus Cannabis Toxicity in the Emergency Department - PMC
• Study: Cannabis a double-edged sword | Newsroom - McGill University
• Sub-chronic effects of s-limonene on brain neurotransmitter levels and behavior of rats - PubMed
• Myrcene—What Are the Potential Health Benefits of This Flavouring and Aroma Agent? - PMC
• Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status - ScienceDirect